Why I don't Like BLUP

Down the rabbit hole into bizarre 20th century statistics

I was getting into GWAS methods for estimating heritability, and it turns out there are two major statistical practices used for this, GCTA and LDSC. The older one is GCTA, so naturally I started reading about it first.

This set me down a rabbit hole of confusion. Whereas LDSC and everything else I’ve seen uses standard OLS, GCTA does not. GCTA uses “BL…